ARID2

AT rich interactive domain 2

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function summary function summary

a subunit of the PBAF complexes involved in ligand-dependent transcriptional activation by nuclear receptors through chromatin remodelling [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
differentiation and development differentiation and development ARID2-containing complexes play a critical role in promoting osteoblast commitment and differentiation [Pubmed]; required for heart morphogenesis and coronary artery development [Pubmed]
types of alteration in cancer types of alteration in cancer inactivating mutations and deletions tend to be acquired as early events in MDS [Pubmed]
genome instability and mutations genome instability and mutations
 
 

KO impairs NER through inhibiting the recruitment of XPG, resulting in susceptibility to carcinogens and potential hypermutation in hepatocellular carcinoma JHH4 cell line [Pubmed]; recruits Rad51 to DNA DSBs to enable their repair by homologous recombination [Pubmed]

suppression of growth suppression of growth
 

suppresses tumour cell growth through repression of cyclin D1 and cyclin E1 expression, thereby retarding cell cycle progression and cell proliferation in hepatoma [Pubmed]