ARID1A

AT rich interactive domain 1A (SWI-like)

switch view
function summary function summary

member of human SWI-SNF complexes [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, fusion
global regulation of gene expression global regulation of gene expression ARID1A loss disrupts SWI/SNF targeting to enhancers to alter gene expression and drive tumorigenesis in colorectal cancer [Pubmed]
differentiation and development differentiation and development ARID1A-depleted cells fail to undergo normal differentiation-associated cell cycle arrest [Pubmed]
types of alteration in cancer types of alteration in cancer frequent inactivating mutations in ovarian cancer, digestive tract cancers, bladder cancer [Pubmed]; recurrent R1989* in endometrioid carcinoma [Pubmed]
impact of mutation on function impact of mutation on function in-frame deletions affecting the consensus nuclear export signal reduce steady-state protein levels of ARID1A, as it is rapidly degraded by the ubiquitin-proteasome system in the nucleus [Pubmed]
fusion partner fusion partner MAST2 in triple-negative breast cancer [Pubmed]
genome instability and mutations genome instability and mutations
 
 

recruited to DNA double-strand breaks (DSB) via its interaction with the upstream DNA damage checkpoint kinase ATR, facilitates efficient processing of DSB to single-strand ends and sustains DNA damage signalling [Pubmed]

cell replicative immortality cell replicative immortality
 
 

ARID1A deficiency compromises ES cell pluripotency, severely inhibits self-renewal, and promotes differentiation into primitive endoderm-like cells [Pubmed]; negatively regulates TERT transcriptional regulation and activity via binding to the regulatory element of TERT, loss of ARID1A protein expression caused by inactivating mutations reactivates TERT transcriptional activity [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

KD promoted proliferation and inhibited 5-fluorouracil-induced apoptosis in colon cancer SW480 cell line [Pubmed]; ARID1A LOF inactivates the apoptosis-promoting function of p53 by upregulating HDAC6, which directly deacetylates Lys120 of p53, a pro-apoptotic post-translational modification [Pubmed]

invasion and metastasis invasion and metastasis
 
 

represses hepatocellular carcinoma cell migration through lncRNA MVIH [Pubmed]

suppression of growth suppression of growth
 

re-expression in cells lacking functional ARID1A results in significant inhibition of colony formation in breast cancer T47D cell line [Pubmed]; KD in immortalised ovary epithelial cells is sufficient to enhance cellular proliferation and tumorigenicity [Pubmed]; silencing ARID1A expression significantly enhances cell growth rate in gastric epithelium GES1 cell line [Pubmed]; represses hepatocellular carcinoma cell proliferation through lncRNA MVIH in hepatocellular carcinoma [Pubmed]