AMER1

APC membrane recruitment protein 1

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function summary function summary

binds to the tumour suppressor APC and acts as an inhibitor of Wnt signalling by inducing beta-catenin degradation [Pubmed]; inhibits the ubiquitination of NRF2; AMER1 and NRF2 compete for binding to KEAP1 [Pubmed]; enhances p53 acetylation by CBP/p300 [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
types of alteration in cancer types of alteration in cancer frequently deleted in Wilms tumour [Pubmed]; recurrent nonsense mutations in colon cancer and Wilms tumour [Pubmed]
impact of mutation on function impact of mutation on function loss of AMER1 leads to rapid ubiquitination and degradation of NRF2 and a reduced response to cytotoxic insult [Pubmed]
suppression of growth suppression of growth
 

promotes beta-catenin ubiquitination and degradation, which antagonize WNT/beta-catenin signalling [Pubmed]; induction of AMER1 inhibits cell growth and causes G(1)/G(0) arrest [Pubmed]