This census gene has a hallmark. For more information please look
[here].
role in cancer | fusion, oncogene | |
---|---|---|
types of alteration in cancer | overexpressed [Pubmed]; recurrent F1174L, R1275Q [Pubmed] | |
impact of mutation on function | F1174S causes ligand-independent activity in neuroblastoma [Pubmed]; R1275Q causes ligand-independent activity in neuroblastoma [Pubmed]; de novo alternative transcription initiation site results in shorter, constitutively active isoform in melanoma [Pubmed]; regulatory domain is absent in fusion protein resulting in constitutive activation [Pubmed] | |
fusion partner | NPM1 in anaplastic large-cell non-Hodgkin's lymphoma [Pubmed]; KIF5B, TFG, KLC1, PTPN3, HIP1, STRN, TPR in NSCLC; ALO17, TFG, MSN, TPM3, TPM4, ATIC, MYH9, CLTC, TRAF1 in ALCL [Pubmed] |
escaping programmed cell death
in the absence of a ligand ALK is kinase inactive and its overexpression results in enhanced apoptosis, kinase activation, due to a ligand or constitutive, as in ALK fusion proteins, decreases apoptosis [Pubmed]
proliferative signalling
enhances cell proliferation [Pubmed]
invasion and metastasis
stimulates the cell migration [Pubmed]