ALK

anaplastic lymphoma kinase (Ki-1)

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function summary function summary

transmembrane receptor-tyrosine kinase, [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion, oncogene
types of alteration in cancer types of alteration in cancer overexpressed [Pubmed]; recurrent F1174L, R1275Q [Pubmed]
impact of mutation on function impact of mutation on function F1174S causes ligand-independent activity in neuroblastoma [Pubmed]; R1275Q causes ligand-independent activity in neuroblastoma [Pubmed]; de novo alternative transcription initiation site results in shorter, constitutively active isoform in melanoma [Pubmed]; regulatory domain is absent in fusion protein resulting in constitutive activation [Pubmed]
fusion partner fusion partner NPM1 in anaplastic large-cell non-Hodgkin's lymphoma [Pubmed]; KIF5B, TFG, KLC1, PTPN3, HIP1, STRN, TPR in NSCLC; ALO17, TFG, MSN, TPM3, TPM4, ATIC, MYH9, CLTC, TRAF1 in ALCL [Pubmed]
escaping programmed cell death escaping programmed cell death
 
 

in the absence of a ligand ALK is kinase inactive and its overexpression results in enhanced apoptosis, kinase activation, due to a ligand or constitutive, as in ALK fusion proteins, decreases apoptosis [Pubmed]

proliferative signalling proliferative signalling
 

enhances cell proliferation [Pubmed]

invasion and metastasis invasion and metastasis
 
 

stimulates the cell migration [Pubmed]