AKT1

v-akt murine thymoma viral oncogene homolog 1

switch view
function summary function summary

fibroblasts lacking Akt1 are resistant to transformation by mutant K-ras and stimulation by epidermal growth factor in lung cancer [Pubmed]; serine/threonine kinase, a component of PI3K/Akt pathway, activated by phosphatidylinositol 3,4,5-trisphosphate (PIP3), translocates to the cell membrane, where it's activated via phosphorylation [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
types of alteration in cancer types of alteration in cancer amplified in gastric adenocarcinoma [Pubmed]; E17K was the only known driver alteration found in a subset of samples in breast cancer [Pubmed]; recurrent missense E17K [Pubmed]
impact of mutation on function impact of mutation on function Lys 17 alters the electrostatic interactions of the lipid-binding pocket and forms new hydrogen bonds with a phosphoinositide ligand, resulting in hyperactivation of AKT1 by means of pathological localization to the plasma membrane and stimulation of downstream signalling [Pubmed]
genome instability and mutations genome instability and mutations
 
 

E17K GOF mutant accelerates DSB repair and improves survival of irradiated cells in murine prostate cancer Tramp-C1 cell line [Pubmed]

angiogenesis angiogenesis
 
 

vital for the maintenance of vascular integrity, regulates the proliferation-apoptosis signalling during vascular remodelling, regulates various signalling pathways to affect the balance of pro- and anti-angiogenic factors [Pubmed]; promotes angiogenesis largely due to phosphorylation and regulation of important downstream effectors that promote aspects of angiogenic signalling [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

KD inhibits anchorage-independent cell growth and induces apoptosis in cancer MiaPaCa-2, H460, HCT-15, and HT1080 cell line [Pubmed]; KD results in increased tumour cell apoptosis in response to serum starvation in haemangioma [Pubmed]; promotes growth factor independent survival in a kinase-independent way in melanocytes [Pubmed]; KD results in impaired cell survival in bladder carcinoma T24 cell line [Pubmed]; suppresses the cell apoptosis induced by DNA damage in colorectal cancer HCT116 and HT29 cell line [Pubmed]

proliferative signalling proliferative signalling
 

PCAF-mediated Akt1 acetylation enhances Akt1 phosphorylation at both sites of Thr(308) and Ser(473) and promotes cell proliferation in glioblastoma [Pubmed]; KD results in impaired cell proliferation and colony formation in bladder carcinoma T24 cell line [Pubmed]; induces mammary hyperplasia in breast cancer [Pubmed]

invasion and metastasis invasion and metastasis
 
 

silencing of Akt1 increases the release of TGF-beta1, which induces a change of morphology, cancer cell dissociation, migration and eventually leads to EMT in lung cancer [Pubmed]; enforced expression of Akt1 induces cell migration and invasion in hepatocellular carcinoma HepG2 cell line [Pubmed]; enforced expression of Akt1 suppresses cell migration and invasion in colorectal cancer HCT116 cell line [Pubmed]; KD decreases basal and VEGF-stimulated cell migration in haemangioma [Pubmed]; KD results in impaired cell migration and microinvasion in bladder carcinoma T24 cell line [Pubmed]; inhibition of AKT1 signalling promotes invasion and metastasis of cancer cells with K-RAS or EGFR mutations in NSCLC [Pubmed]

change of cellular energetics change of cellular energetics
 

activation of ATK1 mimics insulin-induced glucose transport and protein synthesis in adipocytes and L6 myotubes [Pubmed]; AKT1 activation is associated with accumulation of aerobic glycolysis metabolites in prostate cancer [Pubmed]

suppression of growth suppression of growth
 

prevents HER2-driven tumorigenesis, in part through negative feedback inhibition of RTK signalling in breast cancer [Pubmed]