fibroblasts lacking Akt1 are resistant to transformation by mutant K-ras and stimulation by epidermal growth factor in lung cancer [Pubmed]; serine/threonine kinase, a component of PI3K/Akt pathway, activated by phosphatidylinositol 3,4,5-trisphosphate (PIP3), translocates to the cell membrane, where it's activated via phosphorylation [Pubmed]