ACVR1

activin A receptor, type I

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function summary function summary

kinase, receptor of bone morphogenetic protein [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
differentiation and development differentiation and development required for chondrogenesis during development [Pubmed]
types of alteration in cancer types of alteration in cancer recurrent GOF mutations in diffuse intrinsic pontine glioma [Pubmed]; recurrent missense mutations G328V, G328E, R206H in paediatric pontine glioma [Pubmed]
escaping programmed cell death escaping programmed cell death
 
 

overexpression of the constitutively active form of ACVR1 results in a marked increase in apoptotic cells in glioma-initiating cells [Pubmed]

proliferative signalling proliferative signalling
 

GOF mutant promotes cell proliferation in immortalized normal human astrocytes [Pubmed]; overexpression of ALK2 results in the autophosphorylation of Smad1/5, leading to consequent increase in cell growth, the effect is reversed after inhibition of ACVR1 in erythroleukaemia TF-1 cell line [Pubmed]

invasion and metastasis invasion and metastasis
 
 

in the presence of constitutively active ACVR1, cell migration is not inhibited by endoglin in prostate cancer PC3-M cell line [Pubmed]