ABL1

v-abl Abelson murine leukemia viral oncogene homolog 1

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function summary function summary

protein-tyrosine kinase, plays a prominent role in cellular responses to genotoxic stress as well as in the regulation of the actin cytoskeleton. [Pubmed]; phosphorylates RAS proteins to allosterically enhance their effector binding capabilities [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion, oncogene
global regulation of gene expression global regulation of gene expression induces stabilisation of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner [Pubmed]
differentiation and development differentiation and development promotes adipocyte differentiation [Pubmed]
fusion partner fusion partner BCR in CML [Pubmed]
genome instability and mutations genome instability and mutations
 
 

interacts constitutively with Rad51 and phosphorylates Rad51 on Tyr-54 upon treatment with ionising radiation to inhibit the binding of Rad51 to DNA and the function of Rad51 in ATP-dependent DNA strand exchange reactions [Pubmed]

angiogenesis angiogenesis
 
 

loss of Abl kinases leads to increased endothelial cell apoptosis both in vitro and in vivo, contributing to vascular dysfunction, infarction, and tissue damage [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

positively regulates DNA damage-induced apoptosis [Pubmed]

proliferative signalling proliferative signalling
 

impairs EGFR internalisation [Pubmed]

invasion and metastasis invasion and metastasis
 
 

Abl-dependent phosphorylation of WAVE3 is critical for the stimulation of lamellipodia formation and cell migration [Pubmed]; promotes osteolytic metastasis by modulating tumour-bone interactions through TAZ and STAT5 signaling in breast cancer [Pubmed]

change of cellular energetics change of cellular energetics
 

regulates autophagy by promoting the trafficking and function of lysosomal components [Pubmed]