The Cancer Mutation Census (CMC) project is an undertaking to classify coding mutations in COSMIC and identify variants driving different types of cancer. The CMC integrates all coding somatic mutations collected by COSMIC with biological and biochemical information from multiple sources, combining data obtained from manual curation and computational analyses. Metrics like ClinVar significance, dN/dS ratios, and variant frequencies in normal populations (gnomAD) have been integrated into this resource. They have been used alongside COSMIC data on mutations' prevalence across 1,500 forms of human cancer. This helps to predict candidates for driver mutations in the coding portion of the genome.
Please refer to the About CMC page to understand more about the project.
There are 3 ways COSMIC data can be downloaded: Download in Browser, Scripted Downloads, and Filtered downloads. To access any of these options, select the release version and the product you want to download (e.g. Breakpoints, Cancer Gene Census), and click on the 'File Name'. This will open up a pop-up window with the 3 options available for download
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As part of COSMIC's strategy, we offer Non-Commercial and Commercial licences to users.
Non-Commercial users: Register and Login to download data from this page
Commercial users: Contact QIAGEN about obtaining a commercial license to access and download the data.
Please refer to our licensing page here to understand if you are a Non-Commercial or Commercial user.
The whole data file can be downloaded in the tar form, this includes the zipped tab-separated data content file and a readme with a description of all file columns.
This feature allows the products to be downloaded programmatically using the command line or scripts. Once select the option for "Scripted download" in the pop-up window, detailed help with examples is provided on the web page to guide you through the process.
This feature allows a product to be downloaded for a small chunk of data. The categories a product can be filtered on are the Gene symbol, Sample name, and Primary Site (Cancer). The filters could vary depending on the product if it has the filtered fields. E.g. Genome Screen Mutants product can be filtered on all 3 categories of Gene symbol, Sample name, and Primary Site whilst Cancer Gene Census product can only be filtered on Gene Symbols as this product file doesn't include Sample Name or Primary Site.
This feature is currently supported only for the latest release.
Significant enhancements have been implemented to streamline the generation of files for our filters and improve UX.
Changes include: