COSMIC v99, released 28-NOV-23

COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.

Start using COSMIC by searching for a gene, cancer type, mutation, etc. below.


COSMIC is divided into several distinct projects, each presenting a separate dataset or view of our data:

    The core of COSMIC, an expert-curated database of somatic mutations
  • Cell Lines Project
    Mutation profiles of over 1,000 cell lines used in cancer research
    An interactive view of cancer mutations in the context of 3D structures
  • Cancer Gene Census
    A catalogue of genes with mutations that are causally implicated in cancer
  • Cancer Mutation Census
    Classification of genetic variants driving cancer
  • Actionability
    Mutations actionable in precision oncology

Data curation