NOTCH4 ATG CAG CCC CCT TCA CTG CTG CTG CTG CTG CTG CTG CTG CTG CTG CTA TGT GTC TCA GTG 60 M Q P P S L L L L L L L L L L L C V S V 20 GTC AGA CCC AGA GGG CTG CTG TGT GGG AGT TTC CCA GAA CCC TGT GCC AAT GGA GGC ACC 120 V R P R G L L C G S F P E P C A N G G T 40 TGC CTG AGC CTG TCT CTG GGA CAA GGG ACC TGC CAG TGT GCC CCT GGC TTC CTG GGT GAG 180 C L S L S L G Q G T C Q C A P G F L G E 60 ACG TGC CAG TTT CCT GAC CCC TGC CAG AAC GCC CAG CTC TGC CAA AAT GGA GGC AGC TGC 240 T C Q F P D P C Q N A Q L C Q N G G S C 80 CAA GCC CTG CTT CCC GCT CCC CTA GGG CTC CCC AGC TCT CCC TCT CCA TTG ACA CCC AGC 300 Q A L L P A P L G L P S S P S P L T P S 100 TTC TTG TGC ACT TGC CTC CCT GGC TTC ACT GGT GAG AGA TGC CAG GCC AAG CTT GAA GAC 360 F L C T C L P G F T G E R C Q A K L E D 120 CCT TGT CCT CCC TCC TTC TGT TCC AAA AGG GGC CGC TGC CAC ATC CAG GCC TCG GGC CGC 420 P C P P S F C S K R G R C H I Q A S G R 140 CCA CAG TGC TCC TGC ATG CCT GGA TGG ACA GGT GAG CAG TGC CAG CTT CGG GAC TTC TGT 480 P Q C S C M P G W T G E Q C Q L R D F C 160 TCA GCC AAC CCA TGT GTT AAT GGA GGG GTG TGT CTG GCC ACA TAC CCC CAG ATC CAG TGC 540 S A N P C V N G G V C L A T Y P Q I Q C 180 CAC TGC CCA CCG GGC TTC GAG GGC CAT GCC TGT GAA CGT GAT GTC AAC GAG TGC TTC CAG 600 H C P P G F E G H A C E R D V N E C F Q 200 GAC CCA GGA CCC TGC CCC AAA GGC ACC TCC TGC CAT AAC ACC CTG GGC TCC TTC CAG TGC 660 D P G P C P K G T S C H N T L G S F Q C 220 CTC TGC CCT GTG GGG CAG GAG GGT CCA CGT TGT GAG CTG CGG GCA GGA CCC TGC CCT CCT 720 L C P V G Q E G P R C E L R A G P C P P 240 AGG GGC TGT TCG AAT GGG GGC ACC TGC CAG CTG ATG CCA GAG AAA GAC TCC ACC TTT CAC 780 R G C S N G G T C Q L M P E K D S T F H 260 CTC TGC CTC TGT CCC CCA GGT TTC ATA GGC CCA GAC TGT GAG GTG AAT CCA GAC AAC TGT 840 L C L C P P G F I G P D C E V N P D N C 280 GTC AGC CAC CAG TGT CAG AAT GGG GGC ACT TGC CAG GAT GGG CTG GAC ACC TAC ACC TGC 900 V S H Q C Q N G G T C Q D G L D T Y T C 300 CTC TGC CCA GAA ACC TGG ACA GGC TGG GAC TGC TCC GAA GAT GTG GAT GAG TGT GAG ACC 960 L C P E T W T G W D C S E D V D E C E T 320 CAG GGT CCC CCT CAC TGC AGA AAC GGG GGC ACC TGC CAG AAC TCT GCT GGT AGC TTT CAC 1020 Q G P P H C R N G G T C Q N S A G S F H 340 TGC GTG TGT GTG AGT GGC TGG GGC GGC ACA AGC TGT GAG GAG AAC CTG GAT GAC TGT ATT 1080 C V C V S G W G G T S C E E N L D D C I 360 GCT GCC ACC TGT GCC CCG GGA TCC ACC TGC ATT GAC CGG GTG GGC TCT TTC TCC TGC CTC 1140 A A T C A P G S T C I D R V G S F S C L 380 TGC CCA CCT GGA CGC ACA GGA CTC CTG TGC CAC TTG GAA GAC ATG TGT CTG AGC CAG CCG 1200 C P P G R T G L L C H L E D M C L S Q P 400 TGC CAT GGG GAT GCC CAA TGC AGC ACC AAC CCC CTC ACA GGC TCC ACA CTC TGC CTG TGT 1260 C H G D A Q C S T N P L T G S T L C L C 420 CAG CCT GGC TAT TCG GGG CCC ACC TGC CAC CAG GAC CTG GAC GAG TGT CTG ATG GCC CAG 1320 Q P G Y S G P T C H Q D L D E C L M A Q 440 CAA GGC CCA AGT CCC TGT GAA CAT GGC GGT TCC TGC CTC AAC ACT CCT GGC TCC TTC AAC 1380 Q G P S P C E H G G S C L N T P G S F N 460 TGC CTC TGT CCA CCT GGC TAC ACA GGC TCC CGT TGT GAG GCT GAT CAC AAT GAG TGC CTC 1440 C L C P P G Y T G S R C E A D H N E C L 480 TCC CAG CCC TGC CAC CCA GGA AGC ACC TGT CTG GAC CTA CTT GCC ACC TTC CAC TGC CTC 1500 S Q P C H P G S T C L D L L A T F H C L 500 TGC CCG CCA GGC TTA GAA GGG CAG CTC TGT GAG GTG GAG ACC AAC GAG TGT GCC TCA GCT 1560 C P P G L E G Q L C E V E T N E C A S A 520 CCC TGC CTG AAC CAC GCG GAT TGC CAT GAC CTG CTC AAC GGC TTC CAG TGC ATC TGC CTG 1620 P C L N H A D C H D L L N G F Q C I C L 540 CCT GGA TTC TCC GGC ACC CGA TGT GAG GAG GAT ATC GAT GAG TGC AGA AGC TCT CCC TGT 1680 P G F S G T R C E E D I D E C R S S P C 560 GCC AAT GGT GGG CAG TGC CAG GAC CAG CCT GGA GCC TTC CAC TGC AAG TGT CTC CCA GGC 1740 A N G G Q C Q D Q P G A F H C K C L P G 580 TTT GAA GGG CCA CGC TGT CAA ACA GAG GTG GAT GAG TGC CTG AGT GAC CCA TGT CCC GTT 1800 F E G P R C Q T E V D E C L S D P C P V 600 GGA GCC AGC TGC CTT GAT CTT CCA GGA GCC TTC TTT TGC CTC TGC CCC TCT GGT TTC ACA 1860 G A S C L D L P G A F F C L C P S G F T 620 GGC CAG CTC TGT GAG GTT CCC CTG TGT GCT CCC AAC CTG TGC CAG CCC AAG CAG ATA TGT 1920 G Q L C E V P L C A P N L C Q P K Q I C 640 AAG GAC CAG AAA GAC AAG GCC AAC TGC CTC TGT CCT GAT GGA AGC CCT GGC TGT GCC CCA 1980 K D Q K D K A N C L C P D G S P G C A P 660 CCT GAG GAC AAC TGC ACC TGC CAC CAC GGG CAC TGC CAG AGA TCC TCA TGT GTG TGT GAC 2040 P E D N C T C H H G H C Q R S S C V C D 680 GTG GGT TGG ACG GGG CCA GAG TGT GAG GCA GAG CTA GGG GGC TGC ATC TCT GCA CCC TGT 2100 V G W T G P E C E A E L G G C I S A P C 700 GCC CAT GGG GGG ACC TGC TAC CCC CAG CCC TCT GGC TAC AAC TGC ACC TGC CCT ACA GGC 2160 A H G G T C Y P Q P S G Y N C T C P T G 720 TAC ACA GGA CCC ACC TGT AGT GAG GAG ATG ACA GCT TGT CAC TCA GGG CCA TGT CTC AAT 2220 Y T G P T C S E E M T A C H S G P C L N 740 GGC GGC TCC TGC AAC CCT AGC CCT GGA GGC TAC TAC TGC ACC TGC CCT CCA AGC CAC ACA 2280 G G S C N P S P G G Y Y C T C P P S H T 760 GGG CCC CAG TGC CAA ACC AGC ACT GAC TAC TGT GTG TCT GCC CCG TGC TTC AAT GGG GGT 2340 G P Q C Q T S T D Y C V S A P C F N G G 780 ACC TGT GTG AAC AGG CCT GGC ACC TTC TCC TGC CTC TGT GCC ATG GGC TTC CAG GGC CCG 2400 T C V N R P G T F S C L C A M G F Q G P 800 CGC TGT GAG GGA AAG CTC CGC CCC AGC TGT GCA GAC AGC CCC TGT AGG AAT AGG GCA ACC 2460 R C E G K L R P S C A D S P C R N R A T 820 TGC CAG GAC AGC CCT CAG GGT CCC CGC TGC CTC TGC CCC ACT GGC TAC ACC GGA GGC AGC 2520 C Q D S P Q G P R C L C P T G Y T G G S 840 TGC CAG ACT CTG ATG GAC TTA TGT GCC CAG AAG CCC TGC CCA CGC AAT TCC CAC TGC CTC 2580 C Q T L M D L C A Q K P C P R N S H C L 860 CAG ACT GGG CCC TCC TTC CAC TGC TTG TGC CTC CAG GGA TGG ACC GGG CCT CTC TGC AAC 2640 Q T G P S F H C L C L Q G W T G P L C N 880 CTT CCA CTG TCC TCC TGC CAG AAG GCT GCA CTG AGC CAA GGC ATA GAC GTC TCT TCC CTT 2700 L P L S S C Q K A A L S Q G I D V S S L 900 TGC CAC AAT GGA GGC CTC TGT GTC GAC AGC GGC CCC TCC TAT TTC TGC CAC TGC CCC CCT 2760 C H N G G L C V D S G P S Y F C H C P P 920 GGA TTC CAA GGC AGC CTG TGC CAG GAT CAC GTG AAC CCA TGT GAG TCC AGG CCT TGC CAG 2820 G F Q G S L C Q D H V N P C E S R P C Q 940 AAC GGG GCC ACC TGC ATG GCC CAG CCC AGT GGG TAT CTC TGC CAG TGT GCC CCA GGC TAC 2880 N G A T C M A Q P S G Y L C Q C A P G Y 960 GAT GGA CAG AAC TGC TCA AAG GAA CTC GAT GCT TGT CAG TCC CAA CCC TGT CAC AAC CAT 2940 D G Q N C S K E L D A C Q S Q P C H N H 980 GGA ACC TGT ACT CCC AAA CCT GGA GGA TTC CAC TGT GCC TGC CCT CCA GGC TTT GTG GGG 3000 G T C T P K P G G F H C A C P P G F V G 1000 CTA CGC TGT GAG GGA GAC GTG GAC GAG TGT CTG GAC CAG CCC TGC CAC CCC ACA GGC ACT 3060 L R C E G D V D E C L D Q P C H P T G T 1020 GCA GCC TGC CAC TCT CTG GCC AAT GCC TTC TAC TGC CAG TGT CTG CCT GGA CAC ACA GGC 3120 A A C H S L A N A F Y C Q C L P G H T G 1040 CAG TGG TGT GAG GTG GAG ATA GAC CCC TGC CAC AGC CAA CCC TGC TTT CAT GGA GGG ACC 3180 Q W C E V E I D P C H S Q P C F H G G T 1060 TGT GAG GCC ACA GCA GGA TCA CCC CTG GGT TTC ATC TGC CAC TGC CCC AAG GGT TTT GAA 3240 C E A T A G S P L G F I C H C P K G F E 1080 GGC CCC ACC TGC AGC CAC AGG GCC CCT TCC TGC GGC TTC CAT CAC TGC CAC CAC GGA GGC 3300 G P T C S H R A P S C G F H H C H H G G 1100 CTG TGT CTG CCC TCC CCT AAG CCA GGC TTC CCA CCA CGC TGT GCC TGC CTC AGT GGC TAT 3360 L C L P S P K P G F P P R C A C L S G Y 1120 GGG GGT CCT GAC TGC CTG ACC CCA CCA GCT CCT AAA GGC TGT GGC CCT CCC TCC CCA TGC 3420 G G P D C L T P P A P K G C G P P S P C 1140 CTA TAC AAT GGC AGC TGC TCA GAG ACC ACG GGC TTG GGG GGC CCA GGC TTT CGA TGC TCC 3480 L Y N G S C S E T T G L G G P G F R C S 1160 TGC CCT CAC AGC TCT CCA GGG CCC CGG TGT CAG AAA CCC GGA GCC AAG GGG TGT GAG GGC 3540 C P H S S P G P R C Q K P G A K G C E G 1180 AGA AGT GGA GAT GGG GCC TGC GAT GCT GGC TGC AGT GGC CCG GGA GGA AAC TGG GAT GGA 3600 R S G D G A C D A G C S G P G G N W D G 1200 GGG GAC TGC TCT CTG GGA GTC CCA GAC CCC TGG AAG GGC TGC CCC TCC CAC TCT CGG TGC 3660 G D C S L G V P D P W K G C P S H S R C 1220 TGG CTT CTC TTC CGG GAC GGG CAG TGC CAC CCA CAG TGT GAC TCT GAA GAG TGT CTG TTT 3720 W L L F R D G Q C H P Q C D S E E C L F 1240 GAT GGC TAC GAC TGT GAG ACC CCT CCA GCC TGC ACT CCA GCC TAT GAC CAG TAC TGC CAT 3780 D G Y D C E T P P A C T P A Y D Q Y C H 1260 GAT CAC TTC CAC AAC GGG CAC TGT GAG AAA GGC TGC AAC ACT GCA GAG TGT GGC TGG GAT 3840 D H F H N G H C E K G C N T A E C G W D 1280 GGA GGT GAC TGC AGG CCT GAA GAT GGG GAC CCA GAG TGG GGG CCC TCC CTG GCC CTG CTG 3900 G G D C R P E D G D P E W G P S L A L L 1300 GTG GTA CTG AGC CCC CCA GCC CTA GAC CAG CAG CTG TTT GCC CTG GCC CGG GTG CTG TCC 3960 V V L S P P A L D Q Q L F A L A R V L S 1320 CTG ACT CTG AGG GTA GGA CTC TGG GTA AGG AAG GAT CGT GAT GGC AGG GAC ATG GTG TAC 4020 L T L R V G L W V R K D R D G R D M V Y 1340 CCC TAT CCT GGG GCC CGG GCT GAA GAA AAG CTA GGA GGA ACT CGG GAC CCC ACC TAT CAG 4080 P Y P G A R A E E K L G G T R D P T Y Q 1360 GAG AGA GCA GCC CCT CAA ACG CAG CCC CTG GGC AAG GAG ACC GAC TCC CTC AGT GCT GGG 4140 E R A A P Q T Q P L G K E T D S L S A G 1380 TTT GTG GTG GTC ATG GGT GTG GAT TTG TCC CGC TGT GGC CCT GAC CAC CCG GCA TCC CGC 4200 F V V V M G V D L S R C G P D H P A S R 1400 TGT CCC TGG GAC CCT GGG CTT CTA CTC CGC TTC CTT GCT GCG ATG GCT GCA GTG GGA GCC 4260 C P W D P G L L L R F L A A M A A V G A 1420 CTG GAG CCC CTG CTG CCT GGA CCA CTG CTG GCT GTC CAC CCT CAT GCA GGG ACC GCA CCC 4320 L E P L L P G P L L A V H P H A G T A P 1440 CCT GCC AAC CAG CTT CCC TGG CCT GTG CTG TGC TCC CCA GTG GCC GGG GTG ATT CTC CTG 4380 P A N Q L P W P V L C S P V A G V I L L 1460 GCC CTA GGG GCT CTT CTC GTC CTC CAG CTC ATC CGG CGT CGA CGC CGA GAG CAT GGA GCT 4440 A L G A L L V L Q L I R R R R R E H G A 1480 CTC TGG CTG CCC CCT GGT TTC ACT CGA CGG CCT CGG ACT CAG TCA GCT CCC CAC CGA CGC 4500 L W L P P G F T R R P R T Q S A P H R R 1500 CGG CCC CCA CTA GGC GAG GAC AGC ATT GGT CTC AAG GCA CTG AAG CCA AAG GCA GAA GTT 4560 R P P L G E D S I G L K A L K P K A E V 1520 GAT GAG GAT GGA GTT GTG ATG TGC TCA GGC CCT GAG GAG GGA GAG GAG GTG GGC CAG GCT 4620 D E D G V V M C S G P E E G E E V G Q A 1540 GAA GAA ACA GGC CCA CCC TCC ACG TGC CAG CTC TGG TCT CTG AGT GGT GGC TGT GGG GCG 4680 E E T G P P S T C Q L W S L S G G C G A 1560 CTC CCT CAG GCA GCC ATG CTA ACT CCT CCC CAG GAA TCT GAG ATG GAA GCC CCT GAC CTG 4740 L P Q A A M L T P P Q E S E M E A P D L 1580 GAC ACC CGT GGA CCT GAT GGG GTG ACA CCC CTG ATG TCA GCA GTT TGC TGT GGG GAA GTA 4800 D T R G P D G V T P L M S A V C C G E V 1600 CAG TCC GGG ACC TTC CAA GGG GCA TGG TTG GGA TGT CCT GAG CCC TGG GAA CCT CTG CTG 4860 Q S G T F Q G A W L G C P E P W E P L L 1620 GAT GGA GGG GCC TGT CCC CAG GCT CAC ACC GTG GGC ACT GGG GAG ACC CCC CTG CAC CTG 4920 D G G A C P Q A H T V G T G E T P L H L 1640 GCT GCC CGA TTC TCC CGG CCA ACC GCT GCC CGC CGC CTC CTT GAG GCT GGA GCC AAC CCC 4980 A A R F S R P T A A R R L L E A G A N P 1660 AAC CAG CCA GAC CGG GCA GGG CGC ACA CCC CTT CAT GCT GCT GTG GCT GCT GAT GCT CGG 5040 N Q P D R A G R T P L H A A V A A D A R 1680 GAG GTC TGC CAG CTT CTG CTC CGT AGC AGA CAA ACT GCA GTG GAC GCT CGC ACA GAG GAC 5100 E V C Q L L L R S R Q T A V D A R T E D 1700 GGG ACC ACA CCC TTG ATG CTG GCT GCC AGG CTG GCG GTG GAA GAC CTG GTT GAA GAA CTG 5160 G T T P L M L A A R L A V E D L V E E L 1720 ATT GCA GCC CAA GCA GAC GTG GGG GCC AGA GAT AAA TGG GGG AAA ACT GCG CTG CAC TGG 5220 I A A Q A D V G A R D K W G K T A L H W 1740 GCT GCT GCC GTG AAC AAC GCC CGA GCC GCC CGC TCG CTT CTC CAG GCC GGA GCC GAT AAA 5280 A A A V N N A R A A R S L L Q A G A D K 1760 GAT GCC CAG GAC AAC AGG GAG CAG ACG CCG CTA TTC CTG GCG GCG CGG GAA GGA GCG GTG 5340 D A Q D N R E Q T P L F L A A R E G A V 1780 GAA GTA GCC CAG CTA CTG CTG GGG CTG GGG GCA GCC CGA GAG CTG CGG GAC CAG GCT GGG 5400 E V A Q L L L G L G A A R E L R D Q A G 1800 CTA GCG CCG GCG GAC GTC GCT CAC CAA CGT AAC CAC TGG GAT CTG CTG ACG CTG CTG GAA 5460 L A P A D V A H Q R N H W D L L T L L E 1820 GGG GCT GGG CCA CCA GAG GCC CGT CAC AAA GCC ACG CCG GGC CGC GAG GCT GGG CCC TTC 5520 G A G P P E A R H K A T P G R E A G P F 1840 CCG CGC GCA CGG ACG GTG TCA GTA AGC GTG CCC CCG CAT GGG GGC GGG GCT CTG CCG CGC 5580 P R A R T V S V S V P P H G G G A L P R 1860 TGC CGG ACG CTG TCA GCC GGA GCA GGC CCT CGT GGG GGC GGA GCT TGT CTG CAG GCT CGG 5640 C R T L S A G A G P R G G G A C L Q A R 1880 ACT TGG TCC GTA GAC TTG GCT GCG CGG GGG GGC GGG GCC TAT TCT CAT TGC CGG AGC CTC 5700 T W S V D L A A R G G G A Y S H C R S L 1900 TCG GGA GTA GGA GCA GGA GGA GGC CCG ACC CCT CGC GGC CGT AGG TTT TCT GCA GGC ATG 5760 S G V G A G G G P T P R G R R F S A G M 1920 CGC GGG CCT CGG CCC AAC CCT GCG ATA ATG CGA GGA AGA TAC GGA GTG GCT GCC GGG CGC 5820 R G P R P N P A I M R G R Y G V A A G R 1940 GGA GGC AGG GTC TCA ACG GAT GAC TGG CCC TGT GAT TGG GTG GCC CTG GGA GCT TGC GGT 5880 G G R V S T D D W P C D W V A L G A C G 1960 TCT GCC TCC AAC ATT CCG ATC CCG CCT CCT TGC CTT ACT CCG TCC CCG GAG CGG GGA TCA 5940 S A S N I P I P P P C L T P S P E R G S 1980 CCT CAA CTT GAC TGT GGT CCC CCA GCC CTC CAA GAA ATG CCC ATA AAC CAA GGA GGA GAG 6000 P Q L D C G P P A L Q E M P I N Q G G E 2000 GGT AAA AAA TAG 6012 G K K * 2004