DROSHA ATG ATG CAG GGA AAC ACA TGT CAC AGA ATG TCG TTC CAC CCG GGA CGA GGG TGT CCC CGA 60 M M Q G N T C H R M S F H P G R G C P R 20 GGA CGA GGA GGA CAT GGA GCC AGA CCC TCA GCA CCA TCC TTT AGG CCC CAA AAT CTG AGG 120 G R G G H G A R P S A P S F R P Q N L R 40 CTG CTT CAC CCT CAG CAG CCT CCT GTG CAA TAT CAA TAT GAA CCT CCA AGT GCC CCT TCC 180 L L H P Q Q P P V Q Y Q Y E P P S A P S 60 ACC ACT TTC TCA AAC TCT CCA GCC CCC AAT TTT CTC CCT CCA CGA CCA GAC TTT GTA CCC 240 T T F S N S P A P N F L P P R P D F V P 80 TTC CCC CCA CCC ATG CCT CCG TCA GCG CAA GGC CCT CTT CCC CCC TGC CCA ATC AGG CCG 300 F P P P M P P S A Q G P L P P C P I R P 100 CCT TTC CCC AAC CAC CAG ATG AGG CAC CCC TTC CCA GTT CCT CCT TGT TTT CCT CCC ATG 360 P F P N H Q M R H P F P V P P C F P P M 120 CCA CCA CCA ATG CCT TGT CCT AAT AAC CCC CCA GTC CCT GGG GCA CCT CCT GGA CAA GGC 420 P P P M P C P N N P P V P G A P P G Q G 140 ACT TTC CCC TTC ATG ATG CCC CCT CCC TCC ATG CCT CAT CCC CCG CCC CCT CCA GTC ATG 480 T F P F M M P P P S M P H P P P P P V M 160 CCG CAG CAG GTT AAT TAT CAG TAC CCT CCG GGC TAT TCT CAC CAC AAC TTC CCA CCT CCC 540 P Q Q V N Y Q Y P P G Y S H H N F P P P 180 AGT TTT AAT AGT TTC CAG AAC AAC CCT AGT TCT TTC CTG CCC AGT GCT AAT AAC AGC AGT 600 S F N S F Q N N P S S F L P S A N N S S 200 AGT CCT CAT TTC AGA CAT CTC CCT CCA TAC CCA CTC CCA AAG GCT CCC AGT GAG AGA AGG 660 S P H F R H L P P Y P L P K A P S E R R 220 TCC CCA GAA AGG CTG AAA CAC TAT GAT GAC CAC AGG CAC CGA GAT CAC AGT CAT GGG CGA 720 S P E R L K H Y D D H R H R D H S H G R 240 GGT GAG AGG CAT CGG TCC CTG GAT CGG CGG GAG CGA GGC CGC AGT CCC GAC AGG AGA AGA 780 G E R H R S L D R R E R G R S P D R R R 260 CAA GAC AGC CGG TAC AGA TCT GAT TAT GAC CGA GGG AGA ACA CCA TCT CGC CAC CGC AGC 840 Q D S R Y R S D Y D R G R T P S R H R S 280 TAC GAA CGG AGC AGA GAG CGA GAA CGG GAG AGA CAC AGG CAT CGA GAC AAC CGA AGA TCA 900 Y E R S R E R E R E R H R H R D N R R S 300 CCA TCT CTG GAA AGG TCC TAC AAA AAA GAG TAT AAG AGA TCT GGA AGG AGT TAC GGT TTA 960 P S L E R S Y K K E Y K R S G R S Y G L 320 TCG GTT GTT CCT GAA CCT GCT GGA TGC ACA CCA GAA TTA CCT GGG GAG ATT ATT AAA AAT 1020 S V V P E P A G C T P E L P G E I I K N 340 ACA GAT TCT TGG GCC CCA CCC CTG GAG ATT GTG AAT CAT CGC TCC CCA AGT AGG GAG AAG 1080 T D S W A P P L E I V N H R S P S R E K 360 AAG AGA GCT CGT TGG GAG GAA GAA AAA GAC CGT TGG AGT GAC AAC CAG AGT TCT GGC AAA 1140 K R A R W E E E K D R W S D N Q S S G K 380 GAC AAG AAC TAT ACC TCA ATC AAG GAA AAA GAG CCC GAG GAG ACC ATG CCT GAC AAG AAT 1200 D K N Y T S I K E K E P E E T M P D K N 400 GAG GAG GAA GAA GAA GAA CTT CTT AAG CCT GTG TGG ATT CGA TGC ACT CAT TCA GAA AAC 1260 E E E E E E L L K P V W I R C T H S E N 420 TAC TAC TCC AGT GAC CCC ATG GAT CAG GTG GGA GAT TCT ACA GTG GTT GGA ACG AGT AGG 1320 Y Y S S D P M D Q V G D S T V V G T S R 440 CTT CGT GAC TTA TAT GAC AAA TTT GAG GAG GAG TTG GGG AGC AGG CAA GAA AAG GCC AAA 1380 L R D L Y D K F E E E L G S R Q E K A K 460 GCT GCT CGG CCT CCG TGG GAA CCT CCA AAG ACG AAG CTC GAT GAA GAT TTA GAG AGT TCC 1440 A A R P P W E P P K T K L D E D L E S S 480 AGT GAA TCC GAG TGT GAG TCT GAT GAG GAC AGC ACC TGT TCT AGC AGC TCA GAC TCT GAA 1500 S E S E C E S D E D S T C S S S S D S E 500 GTT TTT GAC GTT ATT GCA GAA ATC AAA CGC AAA AAG GCC CAC CCT GAC CGA CTT CAT GAT 1560 V F D V I A E I K R K K A H P D R L H D 520 GAA CTT TGG TAC AAC GAT CCA GGC CAG ATG AAT GAT GGA CCA CTC TGC AAA TGC AGC GCA 1620 E L W Y N D P G Q M N D G P L C K C S A 540 AAG GCA AGA CGC ACA GGA ATT AGG CAC AGC ATT TAT CCT GGA GAA GAG GCC ATC AAG CCC 1680 K A R R T G I R H S I Y P G E E A I K P 560 TGT CGT CCT ATG ACC AAC AAT GCT GGC AGA CTT TTC CAC TAC CGG ATC ACA GTC TCC CCG 1740 C R P M T N N A G R L F H Y R I T V S P 580 CCT ACG AAC TTT TTA ACT GAC AGG CCA ACT GTT ATA GAA TAC GAT GAT CAC GAG TAT ATC 1800 P T N F L T D R P T V I E Y D D H E Y I 600 TTT GAA GGA TTT TCT ATG TTT GCA CAT GCC CCC CTG ACC AAT ATT CCA CTG TGT AAA GTA 1860 F E G F S M F A H A P L T N I P L C K V 620 ATT AGA TTC AAC ATA GAC TAC ACG ATT CAT TTC ATT GAA GAG ATG ATG CCG GAG AAT TTT 1920 I R F N I D Y T I H F I E E M M P E N F 640 TGT GTG AAA GGG CTT GAA CTC TTT TCA CTG TTC CTA TTC AGA GAT ATT TTG GAA TTA TAT 1980 C V K G L E L F S L F L F R D I L E L Y 660 GAC TGG AAT CTT AAA GGT CCT TTG TTT GAA GAC AGC CCT CCC TGC TGC CCA AGA TTT CAT 2040 D W N L K G P L F E D S P P C C P R F H 680 TTC ATG CCA CGT TTT GTA AGA TTT CTT CCA GAT GGA GGA AAG GAA GTG CTG TCC ATG CAC 2100 F M P R F V R F L P D G G K E V L S M H 700 CAG ATT CTC CTG TAC TTG TTA AGG TGC AGC AAA GCC CTG GTG CCT GAG GAG GAG ATT GCC 2160 Q I L L Y L L R C S K A L V P E E E I A 720 AAT ATG CTT CAG TGG GAG GAG CTG GAG TGG CAG AAA TAT GCA GAA GAA TGC AAA GGC ATG 2220 N M L Q W E E L E W Q K Y A E E C K G M 740 ATT GTT ACC AAC CCT GGG ACG AAA CCA AGC TCT GTC CGT ATC GAT CAA CTG GAT CGT GAA 2280 I V T N P G T K P S S V R I D Q L D R E 760 CAG TTC AAC CCC GAT GTG ATT ACT TTT CCG ATT ATC GTC CAC TTT GGG ATA CGC CCT GCA 2340 Q F N P D V I T F P I I V H F G I R P A 780 CAG TTG AGT TAT GCA GGA GAC CCA CAG TAC CAA AAA CTG TGG AAG AGT TAT GTG AAA CTT 2400 Q L S Y A G D P Q Y Q K L W K S Y V K L 800 CGC CAC CTC CTA GCA AAT AGT CCC AAA GTC AAA CAA ACT GAC AAA CAG AAG CTG GCA CAG 2460 R H L L A N S P K V K Q T D K Q K L A Q 820 AGG GAG GAA GCC CTC CAA AAA ATA CGG CAG AAG AAT ACA ATG AGA CGA GAA GTA ACG GTG 2520 R E E A L Q K I R Q K N T M R R E V T V 840 GAG CTA AGT AGC CAA GGA TTC TGG AAA ACT GGC ATC CGT TCT GAT GTC TGT CAG CAT GCA 2580 E L S S Q G F W K T G I R S D V C Q H A 860 ATG ATG CTA CCT GTT CTG ACC CAT CAT ATC CGC TAC CAC CAA TGC CTA ATG CAT TTG GAC 2640 M M L P V L T H H I R Y H Q C L M H L D 880 AAG TTG ATA GGA TAT ACT TTC CAA GAT CGT TGT CTG TTG CAG CTG GCC ATG ACT CAT CCA 2700 K L I G Y T F Q D R C L L Q L A M T H P 900 AGT CAT CAT TTA AAT TTT GGA ATG AAT CCT GAT CAT GCC AGG AAT TCA TTA TCT AAC TGT 2760 S H H L N F G M N P D H A R N S L S N C 920 GGA ATT CGG CAG CCC AAA TAC GGA GAC AGA AAA GTT CAT CAC ATG CAC ATG CGG AAG AAA 2820 G I R Q P K Y G D R K V H H M H M R K K 940 GGG ATT AAC ACC TTG ATA AAT ATC ATG TCA CGC CTT GGC CAA GAT GAC CCA ACT CCC TCG 2880 G I N T L I N I M S R L G Q D D P T P S 960 AGG ATT AAC CAC AAT GAA CGG TTG GAA TTC CTG GGT GAT GCT GTT GTT GAA TTT CTG ACC 2940 R I N H N E R L E F L G D A V V E F L T 980 AGC GTC CAT TTG TAC TAT TTG TTT CCT AGT CTG GAA GAA GGA GGA TTA GCA ACC TAT CGG 3000 S V H L Y Y L F P S L E E G G L A T Y R 1000 ACT GCC ATT GTT CAG AAT CAG CAC CTT GCC ATG CTA GCA AAG AAA CTT GAA CTG GAT CGA 3060 T A I V Q N Q H L A M L A K K L E L D R 1020 TTT ATG CTG TAT GCT CAC GGG CCT GAC CTT TGT AGA GAA TCG GAC CTT CGA CAT GCA ATG 3120 F M L Y A H G P D L C R E S D L R H A M 1040 GCC AAT TGT TTT GAA GCG TTA ATA GGA GCT GTT TAC TTG GAG GGA AGC CTG GAG GAA GCC 3180 A N C F E A L I G A V Y L E G S L E E A 1060 AAG CAG TTA TTT GGA CGC TTG CTC TTT AAT GAT CCG GAC CTG CGC GAA GTC TGG CTC AAT 3240 K Q L F G R L L F N D P D L R E V W L N 1080 TAT CCT CTC CAC CCA CTC CAA CTA CAA GAG CCA AAT ACT GAT CGA CAA CTT ATT GAA ACT 3300 Y P L H P L Q L Q E P N T D R Q L I E T 1100 TCT CCA GTT CTA CAA AAA CTT ACT GAG TTT GAA GAA GCA ATT GGA GTA ATT TTT ACT CAT 3360 S P V L Q K L T E F E E A I G V I F T H 1120 GTT CGA CTT CTG GCA AGG GCA TTC ACA TTG AGA ACT GTG GGA TTT AAC CAT CTG ACC CTA 3420 V R L L A R A F T L R T V G F N H L T L 1140 GGC CAC AAT CAG AGA ATG GAA TTC CTA GGT GAC TCC ATA ATG CAA CTG GTA GCC ACA GAG 3480 G H N Q R M E F L G D S I M Q L V A T E 1160 TAC TTA TTC ATT CAT TTC CCA GAT CAT CAT GAA GGA CAC TTA ACT TTG TTG CGA AGC TCT 3540 Y L F I H F P D H H E G H L T L L R S S 1180 TTG GTG AAT AAT AGA ACT CAG GCC AAG GTA GCG GAG GAG CTG GGC ATG CAG GAG TAC GCC 3600 L V N N R T Q A K V A E E L G M Q E Y A 1200 ATA ACC AAC GAC AAG ACC AAG AGG CCT GTG GCG CTT CGC ACC AAG ACC TTG GCG GAC CTT 3660 I T N D K T K R P V A L R T K T L A D L 1220 TTG GAA TCA TTT ATT GCA GCG CTG TAC ATT GAT AAG GAT TTG GAA TAT GTT CAT ACT TTC 3720 L E S F I A A L Y I D K D L E Y V H T F 1240 ATG AAT GTC TGC TTC TTT CCA CGA TTG AAA GAG TTC ATT TTG AAT CAG GAT TGG AAT GAC 3780 M N V C F F P R L K E F I L N Q D W N D 1260 CCC AAA TCC CAG CTT CAG CAG TGT TGC TTG ACA CTT AGG ACA GAA GGA AAA GAG CCA GAC 3840 P K S Q L Q Q C C L T L R T E G K E P D 1280 ATT CCT CTG TAC AAG ACT CTG CAG ACA GTG GGC CCA TCC CAT GCC CGA ACC TAC ACT GTG 3900 I P L Y K T L Q T V G P S H A R T Y T V 1300 GCT GTT TAT TTC AAG GGA GAA AGA ATA GGC TGT GGG AAA GGA CCA AGT ATT CAG CAA GCG 3960 A V Y F K G E R I G C G K G P S I Q Q A 1320 GAA ATG GGA GCA GCA ATG GAT GCG CTT GAA AAA TAT AAT TTT CCC CAG ATG GCC CAT CAG 4020 E M G A A M D A L E K Y N F P Q M A H Q 1340 AAG CGG TTC ATC GAA CGG AAG TAC AGA CAA GAG TTA AAA GAA ATG AGG TGG GAA AGA GAG 4080 K R F I E R K Y R Q E L K E M R W E R E 1360 CAT CAA GAG AGA GAG CCA GAT GAG ACT GAA GAC ATC AAG AAA TAA 4125 H Q E R E P D E T E D I K K * 1375