ADAMTS13 ATG CAC CAG CGT CAC CCC CGG GCA AGA TGC CCT CCC CTC TGT GTG GCC GGA ATC CTT GCC 60 M H Q R H P R A R C P P L C V A G I L A 20 TGT GGC TTT CTC CTG GGC TGC TGG GGA CCC TCC CAT TTC CAG CAG AGT TGT CTT CAG GCT 120 C G F L L G C W G P S H F Q Q S C L Q A 40 TTG GAG CCA CAG GCC GTG TCT TCT TAC TTG AGC CCT GGT GCT CCC TTA AAA GGC CGC CCT 180 L E P Q A V S S Y L S P G A P L K G R P 60 CCT TCC CCT GGC TTC CAG AGG CAG AGG CAG AGG CAG AGG CGG GCT GCA GGC GGC ATC CTA 240 P S P G F Q R Q R Q R Q R R A A G G I L 80 CAC CTG GAG CTG CTG GTG GCC GTG GGC CCC GAT GTC TTC CAG GCT CAC CAG GAG GAC ACA 300 H L E L L V A V G P D V F Q A H Q E D T 100 GAG CGC TAT GTG CTC ACC AAC CTC AAC ATC GGG GCA GAA CTG CTT CGG GAC CCG TCC CTG 360 E R Y V L T N L N I G A E L L R D P S L 120 GGG GCT CAG TTT CGG GTG CAC CTG GTG AAG ATG GTC ATT CTG ACA GAG CCT GAG GGT GCT 420 G A Q F R V H L V K M V I L T E P E G A 140 CCA AAT ATC ACA GCC AAC CTC ACC TCG TCC CTG CTG AGC GTC TGT GGG TGG AGC CAG ACC 480 P N I T A N L T S S L L S V C G W S Q T 160 ATC AAC CCT GAG GAC GAC ACG GAT CCT GGC CAT GCT GAC CTG GTC CTC TAT ATC ACT AGG 540 I N P E D D T D P G H A D L V L Y I T R 180 TTT GAC CTG GAG TTG CCT GAT GGT AAC CGG CAG GTG CGG GGC GTC ACC CAG CTG GGC GGT 600 F D L E L P D G N R Q V R G V T Q L G G 200 GCC TGC TCC CCA ACC TGG AGC TGC CTC ATT ACC GAG GAC ACT GGC TTC GAC CTG GGA GTC 660 A C S P T W S C L I T E D T G F D L G V 220 ACC ATT GCC CAT GAG ATT GGG CAC AGC TTC GGC CTG GAG CAC GAC GGC GCG CCC GGC AGC 720 T I A H E I G H S F G L E H D G A P G S 240 GGC TGC GGC CCC AGC GGA CAC GTG ATG GCT TCG GAC GGC GCC GCG CCC CGC GCC GGC CTC 780 G C G P S G H V M A S D G A A P R A G L 260 GCC TGG TCC CCC TGC AGC CGC CGG CAG CTG CTG AGC CTG CTC AGC GCA GGA CGG GCG CGC 840 A W S P C S R R Q L L S L L S A G R A R 280 TGC GTG TGG GAC CCG CCG CGG CCT CAA CCC GGG TCC GCG GGG CAC CCG CCG GAT GCG CAG 900 C V W D P P R P Q P G S A G H P P D A Q 300 CCT GGC CTC TAC TAC AGC GCC AAC GAG CAG TGC CGC GTG GCC TTC GGC CCC AAG GCT GTC 960 P G L Y Y S A N E Q C R V A F G P K A V 320 GCC TGC ACC TTC GCC AGG GAG CAC CTG GAT ATG TGC CAG GCC CTC TCC TGC CAC ACA GAC 1020 A C T F A R E H L D M C Q A L S C H T D 340 CCG CTG GAC CAA AGC AGC TGC AGC CGC CTC CTC GTT CCT CTC CTG GAT GGG ACA GAA TGT 1080 P L D Q S S C S R L L V P L L D G T E C 360 GGC GTG GAG AAG TGG TGC TCC AAG GGT CGC TGC CGC TCC CTG GTG GAG CTG ACC CCC ATA 1140 G V E K W C S K G R C R S L V E L T P I 380 GCA GCA GTG CAT GGG CGC TGG TCT AGC TGG GGT CCC CGA AGT CCT TGC TCC CGC TCC TGC 1200 A A V H G R W S S W G P R S P C S R S C 400 GGA GGA GGT GTG GTC ACC AGG AGG CGG CAG TGC AAC AAC CCC AGA CCT GCC TTT GGG GGG 1260 G G G V V T R R R Q C N N P R P A F G G 420 CGT GCA TGT GTT GGT GCT GAC CTC CAG GCC GAG ATG TGC AAC ACT CAG GCC TGC GAG AAG 1320 R A C V G A D L Q A E M C N T Q A C E K 440 ACC CAG CTG GAG TTC ATG TCG CAA CAG TGC GCC AGG ACC GAC GGC CAG CCG CTG CGC TCC 1380 T Q L E F M S Q Q C A R T D G Q P L R S 460 TCC CCT GGC GGC GCC TCC TTC TAC CAC TGG GGT GCT GCT GTA CCA CAC AGC CAA GGG GAT 1440 S P G G A S F Y H W G A A V P H S Q G D 480 GCT CTG TGC AGA CAC ATG TGC CGG GCC ATT GGC GAG AGC TTC ATC ATG AAG CGT GGA GAC 1500 A L C R H M C R A I G E S F I M K R G D 500 AGC TTC CTC GAT GGG ACC CGG TGT ATG CCA AGT GGC CCC CGG GAG GAC GGG ACC CTG AGC 1560 S F L D G T R C M P S G P R E D G T L S 520 CTG TGT GTG TCG GGC AGC TGC AGG ACA TTT GGC TGT GAT GGT AGG ATG GAC TCC CAG CAG 1620 L C V S G S C R T F G C D G R M D S Q Q 540 GTA TGG GAC AGG TGC CAG GTG TGT GGT GGG GAC AAC AGC ACG TGC AGC CCA CGG AAG GGC 1680 V W D R C Q V C G G D N S T C S P R K G 560 TCT TTC ACA GCT GGC AGA GCG AGA GAA TAT GTC ACG TTT CTG ACA GTT ACC CCC AAC CTG 1740 S F T A G R A R E Y V T F L T V T P N L 580 ACC AGT GTC TAC ATT GCC AAC CAC AGG CCT CTC TTC ACA CAC TTG GCG GTG AGG ATC GGA 1800 T S V Y I A N H R P L F T H L A V R I G 600 GGG CGC TAT GTC GTG GCT GGG AAG ATG AGC ATC TCC CCT AAC ACC ACC TAC CCC TCC CTC 1860 G R Y V V A G K M S I S P N T T Y P S L 620 CTG GAG GAT GGT CGT GTC GAG TAC AGA GTG GCC CTC ACC GAG GAC CGG CTG CCC CGC CTG 1920 L E D G R V E Y R V A L T E D R L P R L 640 GAG GAG ATC CGC ATC TGG GGA CCC CTC CAG GAA GAT GCT GAC ATC CAG GTT TAC AGG CGG 1980 E E I R I W G P L Q E D A D I Q V Y R R 660 TAT GGC GAG GAG TAT GGC AAC CTC ACC CGC CCA GAC ATC ACC TTC ACC TAC TTC CAG CCT 2040 Y G E E Y G N L T R P D I T F T Y F Q P 680 AAG CCA CGG CAG GCC TGG GTG TGG GCC GCT GTG CGT GGG CCC TGC TCG GTG AGC TGT GGG 2100 K P R Q A W V W A A V R G P C S V S C G 700 GCA GGG CTG CGC TGG GTA AAC TAC AGC TGC CTG GAC CAG GCC AGG AAG GAG TTG GTG GAG 2160 A G L R W V N Y S C L D Q A R K E L V E 720 ACT GTC CAG TGC CAA GGG AGC CAG CAG CCA CCA GCG TGG CCA GAG GCC TGC GTG CTC GAA 2220 T V Q C Q G S Q Q P P A W P E A C V L E 740 CCC TGC CCT CCC TAC TGG GCG GTG GGA GAC TTC GGC CCA TGC AGC GCC TCC TGT GGG GGT 2280 P C P P Y W A V G D F G P C S A S C G G 760 GGC CTG CGG GAG CGG CCA GTG CGC TGC GTG GAG GCC CAG GGC AGC CTC CTG AAG ACA TTG 2340 G L R E R P V R C V E A Q G S L L K T L 780 CCC CCA GCC CGG TGC AGA GCA GGG GCC CAG CAG CCA GCT GTG GCG CTG GAA ACC TGC AAC 2400 P P A R C R A G A Q Q P A V A L E T C N 800 CCC CAG CCC TGC CCT GCC AGG TGG GAG GTG TCA GAG CCC AGC TCA TGC ACA TCA GCT GGT 2460 P Q P C P A R W E V S E P S S C T S A G 820 GGA GCA GGC CTG GCC TTG GAG AAC GAG ACC TGT GTG CCA GGG GCA GAT GGC CTG GAG GCT 2520 G A G L A L E N E T C V P G A D G L E A 840 CCA GTG ACT GAG GGG CCT GGC TCC GTA GAT GAG AAG CTG CCT GCC CCT GAG CCC TGT GTC 2580 P V T E G P G S V D E K L P A P E P C V 860 GGG ATG TCA TGT CCT CCA GGC TGG GGC CAT CTG GAT GCC ACC TCT GCA GGG GAG AAG GCT 2640 G M S C P P G W G H L D A T S A G E K A 880 CCC TCC CCA TGG GGC AGC ATC AGG ACG GGG GCT CAA GCT GCA CAC GTG TGG ACC CCT GCG 2700 P S P W G S I R T G A Q A A H V W T P A 900 GCA GGG TCG TGC TCC GTC TCC TGC GGG CGA GGT CTG ATG GAG CTG CGT TTC CTG TGC ATG 2760 A G S C S V S C G R G L M E L R F L C M 920 GAC TCT GCC CTC AGG GTG CCT GTC CAG GAA GAG CTG TGT GGC CTG GCA AGC AAG CCT GGG 2820 D S A L R V P V Q E E L C G L A S K P G 940 AGC CGG CGG GAG GTC TGC CAG GCT GTC CCG TGC CCT GCT CGG TGG CAG TAC AAG CTG GCG 2880 S R R E V C Q A V P C P A R W Q Y K L A 960 GCC TGC AGC GTG AGC TGT GGG AGA GGG GTC GTG CGG AGG ATC CTG TAT TGT GCC CGG GCC 2940 A C S V S C G R G V V R R I L Y C A R A 980 CAT GGG GAG GAC GAT GGT GAG GAG ATC CTG TTG GAC ACC CAG TGC CAG GGG CTG CCT CGC 3000 H G E D D G E E I L L D T Q C Q G L P R 1000 CCG GAA CCC CAG GAG GCC TGC AGC CTG GAG CCC TGC CCA CCT AGG TGG AAA GTC ATG TCC 3060 P E P Q E A C S L E P C P P R W K V M S 1020 CTT GGC CCA TGT TCG GCC AGC TGT GGC CTT GGC ACT GCT AGA CGC TCG GTG GCC TGT GTG 3120 L G P C S A S C G L G T A R R S V A C V 1040 CAG CTC GAC CAA GGC CAG GAC GTG GAG GTG GAC GAG GCG GCC TGT GCG GCG CTG GTG CGG 3180 Q L D Q G Q D V E V D E A A C A A L V R 1060 CCC GAG GCC AGT GTC CCC TGT CTC ATT GCC GAC TGC ACC TAC CGC TGG CAT GTT GGC ACC 3240 P E A S V P C L I A D C T Y R W H V G T 1080 TGG ATG GAG TGC TCT GTT TCC TGT GGG GAT GGC ATC CAG CGC CGG CGT GAC ACC TGC CTC 3300 W M E C S V S C G D G I Q R R R D T C L 1100 GGA CCC CAG GCC CAG GCG CCT GTG CCA GCT GAT TTC TGC CAG CAC TTG CCC AAG CCG GTG 3360 G P Q A Q A P V P A D F C Q H L P K P V 1120 ACT GTG CGT GGC TGC TGG GCT GGG CCC TGT GTG GGA CAG GGT ACG CCC AGC CTG GTG CCC 3420 T V R G C W A G P C V G Q G T P S L V P 1140 CAC GAA GAA GCC GCT GCT CCA GGA CGG ACC ACA GCC ACC CCT GCT GGT GCC TCC CTG GAG 3480 H E E A A A P G R T T A T P A G A S L E 1160 TGG TCC CAG GCC CGG GGC CTG CTC TTC TCC CCG GCT CCC CAG CCT CGG CGG CTC CTG CCC 3540 W S Q A R G L L F S P A P Q P R R L L P 1180 GGG CCC CAG GAA AAC TCA GTG CAG TCC AGT GCC TGT GGC AGG CAG CAC CTT GAG CCA ACA 3600 G P Q E N S V Q S S A C G R Q H L E P T 1200 GGA ACC ATT GAC ATG CGA GGC CCA GGG CAG GCA GAC TGT GCA GTG GCC ATT GGG CGG CCC 3660 G T I D M R G P G Q A D C A V A I G R P 1220 CTC GGG GAG GTG GTG ACC CTC CGC GTC CTT GAG AGT TCT CTC AAC TGC AGT GCG GGG GAC 3720 L G E V V T L R V L E S S L N C S A G D 1240 ATG TTG CTG CTT TGG GGC CGG CTC ACC TGG AGG AAG ATG TGC AGG AAG CTG TTG GAC ATG 3780 M L L L W G R L T W R K M C R K L L D M 1260 ACT TTC AGC TCC AAG ACC AAC ACG CTG GTG GTG AGG CAG CGC TGC GGG CGG CCA GGA GGT 3840 T F S S K T N T L V V R Q R C G R P G G 1280 GGG GTG CTG CTG CGG TAT GGG AGC CAG CTT GCT CCT GAA ACC TTC TAC AGA GAA TGT GAC 3900 G V L L R Y G S Q L A P E T F Y R E C D 1300 ATG CAG CTC TTT GGG CCC TGG GGT GAA ATC GTG AGC CCC TCG CTG AGT CCA GCC ACG AGT 3960 M Q L F G P W G E I V S P S L S P A T S 1320 AAT GCA GGG GGC TGC CGG CTC TTC ATT AAT GTG GCT CCG CAC GCA CGG ATT GCC ATC CAT 4020 N A G G C R L F I N V A P H A R I A I H 1340 GCC CTG GCC ACC AAC ATG GGC GCT GGG ACC GAG GGA GCC AAT GCC AGC TAC ATC TTG ATC 4080 A L A T N M G A G T E G A N A S Y I L I 1360 CGG GAC ACC CAC AGC TTG AGG ACC ACA GCG TTC CAT GGG CAG CAG GTG CTC TAC TGG GAG 4140 R D T H S L R T T A F H G Q Q V L Y W E 1380 TCA GAG AGC AGC CAG GCT GAG ATG GAG TTC AGC GAG GGC TTC CTG AAG GCT CAG GCC AGC 4200 S E S S Q A E M E F S E G F L K A Q A S 1400 CTG CGG GGC CAG TAC TGG ACC CTC CAA TCA TGG GTA CCG GAG ATG CAG GAC CCT CAG TCC 4260 L R G Q Y W T L Q S W V P E M Q D P Q S 1420 TGG AAG GGA AAG GAA GGA ACC TGA 4284 W K G K E G T * 1428