GRCh37 · COSMIC v89

Overview

This section shows a general overview of the selected mutation. It describes the source of the mutation i.e gene name/sample name/tissue name with unique ID, and also shows the mutation syntax at the amino acid and nucleotide sequence level. You can see more information on our help pages.

Mutation ID
COSM28061
Gene name
ALK
AA mutation
p.F1174L (Substitution - Missense, position 1174, FL)
CDS mutation
c.3522C>G (Substitution, position 3522, CG)
Nucleotides inserted
n/a
Genomic coordinates
GRCh37, 2:29443695..29443695, view Ensembl contig
CDD
NP_004295.2
HomoloGene
68387, view the multiple sequence alignment
Ever confirmed somatic?
Yes
FATHMM prediction
Pathogenic (score 0.98)
Remark
n/a
Recurrent
n/a
Drug resistance
In the samples curated with this mutation, resistance has been observed for the following drugs. Note that the same resistance pattern may not apply to all samples. For more details, look at the Samples section.
  • Crizotinib

Tissue distribution

This section displays the distribution of mutated samples and tissue types (top 5). You can see more information on our help pages.

Samples

This section displays a table of mutated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED.

Sample name Gene name Transcript Primary Tissue Tissue Subtype 1 Primary Histology Histology Subtype 1 Pubmed ID Zygosity Somatic Status Sample Type LOH Resistant Mutation Drugs

Pathways affected

No pathways affected.

References

This section displays a table of references for the mutation. You can see more information on the help pages.

Reference Title Author Year Journal Status COSMIC Pubmed