Additional information from mouse insertional mutagenesis experiments support TOPBP1 as a cancer driver gene.
Genomic regions are listed below where clusters of insertional events (Common Insertion Sites, CIS) have driven the progression of cancer in mouse models (Ranzani et al; 2013).
Data Source: CCGD (Candidate Cancer Gene Database)
|Insertional Cluster (CIS)
If the frequency of transposon insertions in a given genomic region is higher than expected by chance, the region is called a CIS and the genes within or near this region are identified as candidate cancer genes.