SFPQ

splicing factor proline/glutamine rich(polypyrimidine tract binding protein associated)

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function summary function summary

contains a DNA-binding domain (DBD) that binds to the regulatory region of a proto-oncogene and represses transcription, and 2 RNA-binding domains (RBDs) that bind multiple RNAs, releasing PSF from a repressed proto-oncogene and activating transcription [Pubmed]; activator for the meiosis-specific recombinase DMC1 via its DNA aggregation activity, which increases the local concentrations of ssDNA and dsDNA for homologous pairing by DMC1 [Pubmed]; acts in nuclei, cytoplasm and axons to regulate functionally related mRNAs essential for axon survival [Pubmed]

Suppresses Gene name Field Field Promotes