phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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function summary function summary

p85alpha, stabilizes the p110 alpha, the catalytic subunit of PI3K and inhibits its lipid kinase activity [Pubmed]; homodimeric but not monomeric p85alpha suppresses the PI3K pathway by protecting PTEN from E3 ligase WWP2-mediated proteasomal degradation [Pubmed]

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