familial cylindromatosis gene

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function summary function summary

deubiquitylating enzyme that removes lysine 63-linked polyubiquitin chains from several specific substrates [Pubmed]; a constitutive inhibitor of NF-kB [Pubmed]; regulator of multiple pathways [Pubmed]; regulates the magnitude of ubiquitination of several major effectors of the EGFR pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR complex [Pubmed]

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