This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: TCA cycle genes
- Study ID
- The Krebs cycle (TCA/citric acid cycle) is one of the key metabolic cycles involved in ATP production during aerobic respiration. It is known that tumours tend to favour glycolysis over this cycle. Some Krebs cycle enzymes are tumour suppressors for example succinate dehydrogenase (SDHD, SDHC, SDHB) and fumarate hydratase. When SDH activity is reduced this leads to a pool of succinate which may act as a messenger between mitochondria and the cytosol, ultimately resulting in increased HIF1a levels which may promote tumour progression. The genes in this study all play a role in the Krebs cycle.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples