This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Matrix metallopeptidase family
- Study ID
- The matrix metallopeptidase (MMP) family is a group of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and can process a number of bioactive molecules by, for example, cleavage of cell surface receptors. Their role in extracellular matrix remodelling during cellular invasion gives them an important role in host/tumour cell interaction (e.g. angiogenesis) and mediating the invasive/metastatic behavior of tumour cells. Deregutlated expression of several MMPs have been associated with the pathophysiology of many types of cancer.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples