This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Ubiquitin ligases
- Study ID
- The ubiquitin-proteasome system mediates the degradation of proteins. The attachment of ubiquitin (UB) to a target protein requires the action of three enzymes, called UB-activating enzymes (E1), UB-conjugating enzymes (E2) and UB ligases (E3). E3s determine the substrate specificity and regulation of the ubiquitinylation process. There are at least four classes of E3 ligases: HECT-type, RING-type, PHD-type, and U-box containing. This group of genes contains a selection of HECT and RING type E3s.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples