This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Phospholipase C family
- Study ID
- There are thirteen isozymes of phospholipase C (PLC) split into six different subfamilies each of which is activated by a different stimulus. They can be activated by G protein subunits or transmembrane receptors with intrinsic or associated tyrosine kinase activity. When activated, PLC hydrolyses phosphatidylinositol to form inositol triphosphate (IP3) and diacylglycerol (DAG) which then go on to mediate cell signalling via protein kinase C or Ca2+ release. All thirteen family members are included in this study.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples