This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Cyclins and genes associated with RB
- Study ID
- Cyclins co-ordinate the cell cycle through regulation of cyclin dependant kinases (CDKs) and have very distinct temporal expression at different points of the cell cycle. Activation of CDK4/6 leads to phosphorylation of RB protein leading to its inactivation. In its unphosphorylated (active) state, RB acts as a gatekeeper of the cell cycle, preventing mitosis. Phosphorylation of RB removes this block allowing mitosis to occur. Mutations in RB1 are frequently found in many types of tumour and it was in fact the first known tumour suppressor. This gene set is comprised of cyclins, CDKs and other proteins which interact with RB.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples