This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Notch signalling proteins
- Study ID
- This group of proteins comprise the Notch receptors and other proteins which are involved in Notch signalling. The Notch signalling pathway allows cells to communicate with each other and plays a crucial role in developmental regulation. Notch receptors are membrane bound and are activated upon binding of a ligand found on the surface of another cell. This binding releases the Notch intracellular domain (NICD) by proteolytic cleavage allowing it to translocate to the nucleus. Once in the nucleus, the NICD activates gene transcription with the help of its binding partners. NOTCH1 mutations have been associated with T-cell acute lymphoblastic leukaemia.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples