This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Ubiquitination pathway genes
- Study ID
- The ubiquitin pathway genes are involved in protein ubiquitination. This pathway is responsible for the conjugation of one or more ubiquitin monomers to a target protein by covalent bonding. Poly-ubiquitination (at least four ubiquitin peptides attached to a substrate protein) marks the tagged protein for degradation by the proteasome. Mono-ubiquitination has been shown to target transmembrane receptors for removal from the membranes allowing them to mediate cell signalling. The VHL gene (mutations in which cause Von Hippel-Lindau syndrome) encodes a ubiquitin E3 ligase.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples