This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: GAP-GEF genes
- Study ID
- This gene set, consisting of 173 genes, is comprised of proteins that function to regulate the activity of proteins with GTPase activities. GTPase activating proteins (GAPs) promote hydrolysis of GTP-GDP. Guanine nucleotide exchange factors (GEFs) promote GDP/GTP exchange. Both classes modulate the function of the small monomeric GTPases (including the RAS oncogene family) and other key signalling proteins that use the conversion of GTP-GDP as a molecular switch to regulate function. This system of GTPase/GAP/GEFs regulates a wide variety of cellular processes including growth, differentiation, survival and motility.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples