Somatic mutations of the protein kinase gene family in human lung cancer.

COSU22

Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. In this study, the coding domains of the entire protein kinase gene family (518 genes) have been examined in a collection of lung carcinomas. No commonly mutated kinase domain was found; the mutations were widely spread, mostly missense events with a probable majority of passenger mutations. The mutational spectra of most samples were characterized by a high proportion of C:G > A:T transversions, compatible with the mutagenic effects of tobacco carcinogens. Six samples were observed with more than 10 mutations, with NCI-H1770 the most hypermutable, presenting 49 mutations in this collection of 518 genes. This data is previously published.

518

251