This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Phospholipase D family.
- Study ID
- Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to form phosphatidic acid and choline. The phosphatidic acid may act as a signal molecule (e.g. by activating a PA-activated kinase) or can be hydrolysed to form diacylglycerol by the enzyme PA phosphohydrolase. It is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. PLD is involved in intracellular signalling pathways important in the regulation of cell growth and apoptosis. Overexpression of PLCD has been observed in different types of cancer including breast, gastric and renal. PLCD has also been implicated in metastasis due to its role in cell motility and invasion.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples