This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Small monomeric GTPases
- Study ID
- The small monomeric GTPase family function as key molecular switches
impacting a large variety of cellular functions from motility through
cell signalling to transcription through the binding, hydrolysis and
exchange of GTP/GDP. Members of the RAS subfamily (HRAS, NRAS, KRAS) of small
monomeric GTPases were amongst the first identified human oncogenes and
are mutationally activated in a wide variety of human cancers.
The samples in this study are a set of cancer cell lines that all have a matched normal cell line. All of the mutations are confirmed as somatic.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples