This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Diacylglycerol kinases and other lipid kinases
- Study ID
- Diacylglycerol (DAG) is a second messenger lipid made through the hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C to give DAG and IP3. DAG can then go on to activate the protein kinase C (PKC) signalling pathway. The conversion of DAG to phosphatidic acid (PA) through phosphorylation by DAG lipid kinases (DGKs) reduces DAG activation of PKC while initiating signalling events triggered by PA. Elevated DAG levels leads to cellular transformation via prolonged activation of PKC.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples