This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Cytochrome C oxidase family
- Study ID
- Cytochrome C oxidase is the last enzyme in the electron transport chain. It is a heteromeric complex consisting of 3 mitochondrial encoded catalytic subunits, which function in electron transport, and multiple nuclear encoded structural subunits which are thought to be involved in regulation and assembly of the complex. Cytochrome C oxidase receives an electron from each of four cytochrome c molecules which it uses to create a chemiosmotic potential that drives ATP synthesis. As well as presenting electrons to cytochrome C oxidase, cytochrome C initiates apoptosis when released from the mitochondrion. This gene family is composed of the nuclear encoded genes that either form part of the cytochrome C oxidase complex or are associated with it. COX6C is translocated in uterine leiomyoma.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples