This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: DNA methylation and histone deacetylation
- Study ID
- CpG islands present in the 5prime regulatory regions of many genes modulate transcription of the gene depending on their methylation status. If the CpG island is unmethylated the gene can become transcriptionally active but if it is methylated, gene expression is silenced. Methylation of DNA may physically impede transcription factor binding but more importantly, Methyl-CpG-binding domain proteins (MBDs) bind to the methylated DNA and then recruit histone deacetylases and other chromatin remodelling proteins. Chromatin remodelling then results in gene silencing. Hypermethylation of tumour suppressor genes has been associated with cancer. This gene set is comprised of DNA methyl transferases, which are responsible for methylation, MBDs, histone deacetylases and other proteins involved in methylation and chromatin remodelling.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples