This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Cyclooxygenase family.
- Study ID
- Cyclooxygenase converts arachidonic acid to prostaglandin H2 (PGH2), the precursor of the series-2 prostanoids. Due to this role in prostaglandin synthesis, it is a powerful regulator of the inflammatory response. This gene set also includes prostaglandin E receptors which can couple with both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. Cyclooxygenase-1 (PTGS1) overexpression has been found in several types of cancer.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples