This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Apobec family.
- Study ID
- The Apobec family of proteins can deaminate cytidine in RNA and/or DNA. Apobec-1 is the catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. It is also involved in CGA (Arg) to UGA (Stop) editing in NF1 mRNA. Apobec-1 expression has been found in a subset of tumours from NF patients, particularly those expressing an alternative NF1 transcript which seems to be preferentially deaminated by apobec-1 complex.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples