This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Sirtuin family of proteins, homologs to the yeast Sir2 protein.
- Study ID
- Sirtuins are NAD-dependent histone deacetylases (class 3), which effect cellular metabolism through regulation of gene expression. Increased expression of the yeast Sir2 protein (homologous to human SIRT1) increases the life span of yeast. SIRT1 overexpression has been observed in many cancer types including acute myeloid leukaemia and skin cancer. Tumours with loss of p53 and other tumour suppressor genes have shown increased SIRT1 expression which can lead to transformation and formation of tumours that are addicted to SIRT1 overexpression.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples