This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Growth Arrest Specific Genes.
- Study ID
- Growth arrest specific (GAS) genes were initially identified due to their high expression in 3T3 fibroblasts following growth arrest. The products of these genes can negatively or positively regulate cell proliferation, differentiation and apoptosis. GAS1 has been shown to block the cell cycle at the point of entry into S phase while GAS2 is implicated in morphological changes in the cell leading to apoptosis. Deletions spanning the chromosomal region containing the GAS1 gene have been associated with several types of cancer.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples