This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Serpin/TIMP peptidase inhibitor families
- Study ID
- Serine protease inhibitor (Serpins) are a group of structurally related proteins, many of which inhibit proteases. Inhibitory serpins are typically involved in the regulation of proteolytic cascades that control processes such as blood clotting, the inflammatory and tissue remodelling. Serpins can also play roles distinct from protease inhibition. For example, maspin, a non inhibitory serpin, is important for preventing metastasis in breast and prostate cancers. The proteins encoded by the tissue inhibitor of metallo-proteinase (TIMP) gene family are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples