This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Telomerase complex
- Study ID
- The genes in this study have been identified as contributing to the synthesis/maintenance of telomeres - repetitive DNA structures maintaining chromosomal ends during replication. Most normal adult tissues no longer express the activity, suggesting that loss of sequence at chromosome ends is, at least in part, a molecular clock for cell aging. Reactivation of telomerase is considered a nearly ubiquitous feature of cancers, restoring stability to chromosome ends and forestalling senescence.The samples in this study are a set of cancer cell lines that all have a matched normal cell line. All of the mutations are confirmed as somatic.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples