This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: STAT and SOCS gene families
- Study ID
- STAT proteins have the dual function of signal transduction and activation of transcription. These proteins are activated by phosphorylation on tyrosine in response to different ligands (usually cytokine stimulation) after which they form homodimers or heterodimers that translocate to the cell nucleus where they either directly bind to DNA or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. SOCS proteins negatively regulate cytokine receptor signalling via the JAK/STAT pathway. SOCS1 mutations have been found in Hodgkin lymphoma and mediastinal B-cell lymphoma.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples