This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Pilot: Heterotrimeric G-Proteins
- Study ID
- The heterotrimeric guanine nucleotide-binding proteins are a family of proteins that serve to couple transmembrane cell surface receptor activation to intracellular signalling pathways. Each G protein is composed of three subunits one alpha, beta and gamma subunit - comprised generally of both inhibitory and activating subunits. Upon receptor activation subunits are disassociated transducing signals to downstream effectors. The GNAS gene has been found to be mutated in pituitary adenoma.The samples in this study are a set of cancer cell lines that all have a matched normal cell line. All of the mutations are confirmed as somatic.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples