This tab shows an overview of the mutation data [more details]
Gene Name:
FBXW7
Mutation Id:
COSM22975
AA Mutation:
p.R505C (Substitution - Missense, position 505, RC)
CDS Mutation:
c.1513C>T (Substitution, position 1513, CT)
GRCh38:
4:152326137..152326137, view Ensembl Contig
COSMIC Genome Browser:
4:152326137..152326137, view in COSMIC JBrowse
CDD:
NP_361014.1
Homologene:
117451, view the multiple sequence alignment.
Ever confirmed somatic:
Yes
FATHMM prediction:
Pathogenic (score 0.94)
This tab displays the distribution of mutated samples and tissue types. [more details]
This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene name Transcript Primary Tissue Histology Pubmed ID Zygosity Somatic Status Sample Source LOH Resistant Mutation Drugs
This tab displays a table of pathways affected by the mutation [more details]
SourcePathways
Reactome Metabolism of proteins
WikiPathwayDelta-Notch Signaling Pathway
This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed