This tab shows an overview of the mutation data [more details]
Gene Name:
FBXW7
Mutation Id:
COSM22974
AA Mutation:
p.R479Q (Substitution - Missense, position 479, RQ)
CDS Mutation:
c.1436G>A (Substitution, position 1436, GA)
GRCh38:
4:152326214..152326214, view Ensembl Contig
COSMIC Genome Browser:
4:152326214..152326214, view in COSMIC JBrowse
CDD:
NP_361014.1
Homologene:
117451, view the multiple sequence alignment.
Ever confirmed somatic:
Yes
FATHMM prediction:
Pathogenic (score 0.99)
This tab displays the distribution of mutated samples and tissue types. [more details]
This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene name Transcript Primary Tissue Histology Pubmed ID Zygosity Somatic Status Sample Source LOH Resistant Mutation Drugs
This tab displays a table of pathways affected by the mutation [more details]
SourcePathways
Reactome Metabolism of proteins
WikiPathwayDelta-Notch Signaling Pathway
This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed